Inhibiting the replication of Chikungunya virus replicon particles with antiviral agents, and a traditional herbal tincture Carmol Drops

Chikungunya virus (CHIKV) belongs to the alphavirus genus and is transmitted by mosquitoes. It has spread from the tropics to all continents except Antarctica. Recent cases of CHIKV infection have been reported in Arabia, the United States, Mexico, and even Italy. The virus causes excruciating joint pain lasting for months or even years after the infection. There is neither a …

Synthesis of Haspin-Selective High-Affinity Fluorescent Probe

Protein kinases constitute an enzyme family that catalyzes the phosphorylation of proteins that play vital role in regulation of almost every process in cell. Abnormal protein kinase activity might result in or contribute to a variety of major diseases such as cancer, Alzheimer’s disease, and diabetes. Therefore, the compounds that are able to recognize and block the increased activity of …

Simulation of the collision of binary white dwarfs using a cubic grid – stability analysis by variation of diffusion constant and resolution

Binary star mergers are often studied using computer simulations. Sometimes, however, such simulations turn out to be unstable, if necessary countermeasures are not applied. This paper presents a study of the relationship between the resolution of a simulation and the minimal necessary artificial diffusion to keep it stable. In order to accomplish that, a computer simulator was programmed to simulate …